Mast Cell Mediators in Immediate Allergic Wheal Reaction
نویسنده
چکیده
Mast cells are resident effector cells, which are essential for the elicitation of the allergic response of immediate type. However, the release and significance of different mast cell mediators in the allergic wheal reaction are poorly understood, except for histamine. Therefore, in this study the involvement of mast cell mediators in the allergic prick test wheal induced by cow and bee allergen was investigated, with special attention being paid to histamine, leukotriene C4 (LTC4), prostaglandin D2 (PGD2), tryptase, chymase and interleukin-4 (IL-4).
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